Lipoxygenases in Inflammation by Dieter Steinhilber

Lipoxygenases in Inflammation



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Lipoxygenases in Inflammation Dieter Steinhilber ebook
Page: 245
Format: pdf
Publisher: Springer International Publishing
ISBN: 9783319277646


Reflecting these different functions are lipoxygenases with different characteristics in . The lipoxygenases (LOs) are principal enzymes involved in the oxidative metabolism of polyunsaturated fatty acids, including arachidonic acid. Evidence for activation of inflammatory lipoxygenase pathways in visceral adipose tissue of obese Zucker rats. Type 2 diabetes is associated with obesity, insulin resistance, andinflammation in adipose tissue. Provoke bronchoconstriction and inflammation. Lipoxygenases become candidates for the endogenous capsaicin-. A number of elegant studies over the last thirty years have contributed to unraveling the role that lipoxygenases play in chronic inflammation. Cancer and inflammation are intimately linked due to specific oxidative processes in the tumor microenvironment. Effect of 5-lipoxygenase inhibition on bronchoconstriction and airway inflammation in nocturnal asthma. 5-lipoxygenase deficiency reduces hepatic inflammation and tumor necrosis factor alpha-induced hepatocyte damage in hyperlipidemia-prone ApoE-null mice. Doi: 10.1007/s00109-012-0954-4. In inflammatory hyperalgesia, endogenous activators of VR1 have been suspected. However, the detailed mechanism of how 5-lipoxygenase regulates theinflammatory response in arthritis synovial tissue is still unclear. 12- and 15-lipoxygenases are expressed in many tissues, including adipose tissue. From asthma to atherosclerosis--5-lipoxygenase, leukotrienes, and inflammation.





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